![116817-13-1](/CAS/GIF/116817-13-1.gif)
(±)-Duloxetine synthesis
- Product Name:(±)-Duloxetine
- CAS Number:116817-13-1
- Molecular formula:C18H19NOS
- Molecular Weight:297.41
![(R)-Duloxetine](/CAS/GIF/116539-60-7.gif)
116539-60-7
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116817-13-1
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Yield:116817-13-1 93.8%
Reaction Conditions:
with potassium hydroxide in dimethyl sulfoxide at 105; for 2 h;
Steps:
5
The mother lye obtained in the crystallization process of Example 4 is mixed with 30 ml of 10 percent by weight aqueous sodium hydroxide solution with cooling, the diethylether phase is dried over magnesium sulphate and evaporated to dryness.Yield, 6.5 g yellow oil containing approx. 70.5 percent by weight (-)-N-methyl-3-(l-naphtyloxy)-3-(2-thienyl)-propilamine free base according to HPLC analysis. The oil is mixed with 30 ml of dimethylsulphoxide and 1.0 g potassium hydroxide and the mixture is heated for two hours at the temperature of 105 0C with stirring. The suspension is poured onto the mixture of 50 g of ice and 50 ml of toluene, the phases are separated, the toluene layer is dried and evaporated to dryness.Yield, 6.1 g (93.8 %) yellow oil, which is duloxetine free base racemate according to HPLC analysis.
References:
WO2007/105021,2007,A2 Location in patent:Page/Page column 27
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116817-11-9
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116817-13-1
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116817-13-1
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116817-13-1
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116817-13-1
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$145.00/1g