DIETHYL 4-BROMOBENZYL PHOSPHONATE synthesis
- Product Name:DIETHYL 4-BROMOBENZYL PHOSPHONATE
- CAS Number:38186-51-5
- Molecular formula:C11H16BrO3P
- Molecular Weight:307.12
Yield: 90%
Reaction Conditions:
with tetra-(n-butyl)ammonium iodide at 120; for 24 h;Inert atmosphere;
Steps:
3 Example 3 Triethyl phosphite and 4-bromobenzyl alcohol were used to prepare diethyl 4-bromobenzylphosphonate
To a 20 mL tubular reactor was added 4-bromobenzyl alcohol (93.0 mg, 0.50 mmol)(3.8 mg, 0.01 mmol, 2 mol%), protected by vacuum nitrogen and then heated to 120 ° C under solvent-free conditions 24h After the TLC monitoring reaction was complete, the product was purified by column chromatography and the yield was 90%.
References:
Wenzhou University;Xu Qing;Ma Xiantao;Su Chenliang;Han Libiao CN106543221, 2017, A Location in patent:Paragraph 0030; 0031; 0032; 0033
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