Desonide synthesis
- Product Name:Desonide
- CAS Number:638-94-8
- Molecular formula:C24H32O6
- Molecular Weight:416.51
13951-70-7
334 suppliers
$28.00/1g
67-64-1
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$19.10/10ml
638-94-8
445 suppliers
$23.52/250MG
Yield:638-94-8 85%
Reaction Conditions:
with boron trifluoride in tetrahydrofuran;acetonitrile at -5 - 10;Inert atmosphere;
Steps:
3 preparation of Desonide
Under N2 protection,A mixture of 16α-hydroxyprednisolone (II-1) (5 g, 1.33 mmol)And 47% boron trifluoride tetrahydrofuran solution (0.6 g) were added to acetonitrile (50 ml)The temperature is maintained between -5 ° C and 0 ° C,Acetone (III-2) (1.2 g) was slowly added dropwise,After dripping, the temperature was maintained at 0 to 10 ° C,After 5-6 h reaction, the solid was filtered,The solid was rinsed with acetonitrile and dried to give desonide 4.7g,Yield 85%, purity greater than 99% (HPLC),
References:
CN103421075,2017,B Location in patent:Paragraph 0037-0039
25092-25-5
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638-94-8
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$23.52/250MG
13951-70-7
334 suppliers
$28.00/1g
638-94-8
445 suppliers
$23.52/250MG
37413-91-5
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$50.00/100mg
638-94-8
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77017-20-0
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$640.00/10mg
638-94-8
445 suppliers
$23.52/250MG