CYCLOHEXYL 2-CHLOROACETATE synthesis
- Product Name:CYCLOHEXYL 2-CHLOROACETATE
- CAS Number:6975-91-3
- Molecular formula:C8H13ClO2
- Molecular Weight:176.64
79-11-8
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$27.00/25g
108-93-0
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$11.00/25g
6975-91-3
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$45.00/100mg
Yield:6975-91-3 92%
Reaction Conditions:
with toluene-4-sulfonic acid in toluene; for 4 h;Reflux;
Steps:
4.1 (1) Synthesis of cyclohexyl chloroacetate
A dry three-necked flask is connected to a thermometer, water trap and mechanical stirring. Add 32.4 g (0.32 mol) of cyclohexanol, 33.6 g (0.36 mol) of chloroacetic acid, 1 g of p-toluene sulfonic acid and 100 ml of toluene into the reaction flask, reflux and dehydrate to the theoretical value (about 4 hours) under stirring, GC Analyze that the cyclohexanol content is lower than 0.5% as the end point of the reaction. After cooling to room temperature, the reactants were washed with water, saturated sodium bicarbonate aqueous solution, and water, dried over anhydrous magnesium sulfate, filtered with suction, and the filter cake was washed with toluene. Combine the filtrate and washing liquid, and desolvate to obtain 64 grams of brown liquid. Vacuum distillation collects 52.0 grams of 70-72°C/5mmHg fraction with a yield of 92.0%.
References:
CN112457191,2021,A Location in patent:Paragraph 0051-0053
79-04-9
375 suppliers
$12.00/5g
108-93-0
434 suppliers
$11.00/25g
6975-91-3
31 suppliers
$45.00/100mg