Bromomethanesulphonylbromide synthesis

2synthesis methods

Product Name:Bromomethanesulphonylbromide
CAS Number:54730-18-6
Molecular formula:CH2Br2O2S
Molecular Weight:237.9

Bromomethanesulphonylbromide is prepared as followed: to a stirred suspension of sym-trithiane (0.73 mol) in water was added Br2 (7.1 mol) dropwise to maintain a reaction temperature of 35-40 °C. Cooling by ice bath may be required. After the addition of Br2 is complete, the reaction is stirred for an additional 15 min. The product is extracted into CH2Cl2, washed with 5% sodium bisulfite solution, and dried. Concentration and distillation yields bromomethanesulfonyl bromide in 42-48% yield as a pale yellow liquid.

Methanesulfonyl chloride, 1-(trimethylsilyl)-

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54730-18-6
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10099-08-8
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Yield:10099-08-8 79%

Reaction Conditions:

with tetraethylammonium chloride;bromine;cesium fluoride in acetonitrile;Ambient temperature;addition at 0 deg C;

References:

Block, Eric;Aslam, Mohammad [Tetrahedron Letters,1982,vol. 23,# 41,p. 4203 - 4206]

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References