ChemicalBook CAS DataBase List BETA-CHLOROLACTIC ACID

BETA-CHLOROLACTIC ACID synthesis

12synthesis methods

Product Name:BETA-CHLOROLACTIC ACID
CAS Number:1713-85-5
Molecular formula:C3H5ClO3
Molecular Weight:124.52

106-89-8 Synthesis

106-89-8
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$9.00/10 g

1713-85-5
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$65.00/500mg

Yield:1713-85-5 52%

Reaction Conditions:

with nitric acid at 100; for 12.5 h;Cooling with ice;

Steps:

3.1 Preparation of 3-chloro-2-hydroxypropionic acid
10.0 g of epichlorohydrin was placed in a 250 ml round bottom flask, and iceStirring in a bath, 30 ml of concentrated nitric acid (concentration 65-68%) by dropwise dropwise over about 30 minutes. Remove the ice bath and heat it100 ° C for 12 hours. Add 7 grams of sodium bicarbonate, 50 ml of anhydrous ether extraction four times. The organic phase was dried with anhydrous magnesium sulfateDried, filtered, the filtrate was concentrated in addition to the solvent and recrystallized from trichloromethane to give white crystals of 3-chloro-2-hydroxypropionic acid, yield52%.

References:

China University Of Geoscienceswuhan;ZHANG, Xiaojin;DAI, Yu CN106554342, 2017, A Location in patent:Paragraph 0012-0014

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