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15642-89-4

Benzenemethanol, α-(chloromethyl)-4-methyl- synthesis

4synthesis methods
-

Yield:15642-89-4 95%

Reaction Conditions:

Stage #1: Chloroiodomethanewith TurboGrignard in tetrahydrofuran at -20; for 0.000277778 h;Flow reactor;
Stage #2: 4-methyl-benzaldehyde in tetrahydrofuran at -20; for 0.000444444 h;Flow reactor;Time;

References:

Von Keutz, Timo;Cantillo, David;Kappe, C. Oliver [Organic Letters,2020,vol. 22,# 19,p. 7537 - 7541] Location in patent:supporting information