ChemicalBook CAS DataBase List ARG-GLY-ASP-SER

ARG-GLY-ASP-SER synthesis

8synthesis methods

Product Name:ARG-GLY-ASP-SER
CAS Number:91037-65-9
Molecular formula:C15H27N7O8
Molecular Weight:433.42

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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Yield:-

Steps:

Multi-step reaction with 6 steps
1.1: HCl / ethyl acetate / 2 h / 20 °C
2.1: 1-hydroxybenzotriazole hydrate; N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 0.5 h / 0 °C
2.2: 91 percent / N-methylmorpholine / tetrahydrofuran / 8 h / 20 °C / pH 8.5
3.1: 93 percent / HCl / ethyl acetate / 2 h / 20 °C
4.1: 1-hydroxybenzotriazole hydrate; N,N'-dicyclohexylcarbodiimide / tetrahydrofuran / 0.5 h / 0 °C
4.2: 89 percent / N-methylmorpholine / tetrahydrofuran / 8 h / 20 °C / pH 8.5
5.1: 93 percent / HCl / ethyl acetate / 3 h / 20 °C
6.1: 92 percent / H₂; formic acid / Pd/C / methanol / 24 h / 20 °C / 150.01 Torr

References:

Xiong, Yu;Zhao, Ming;Wang, Chao;Heng, Wei Chang;Peng, Shiqi [Journal of Medicinal Chemistry,2007,vol. 50,# 14,p. 3340 - 3353]