AMINO(3-BROMOPHENYL)ACETIC ACID synthesis
- Product Name:AMINO(3-BROMOPHENYL)ACETIC ACID
- CAS Number:150174-93-9
- Molecular formula:C8H8BrNO2
- Molecular Weight:230.06
79422-72-3
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150174-93-9
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Yield:-
Reaction Conditions:
Stage #1: 5-(3-Bromphenyl)hydantoinwith sodium hydroxide;water at 20; for 240 h;Heating / reflux;
Stage #2: with acetic acid in water; pH=7;
Steps:
19
A stirred mixture of 5-(3-bromophenyl)-2,4-imidazolidinedione (prepared using a similar method to that disclosed in Pharmazie 1981 , 36, 467) (7.8g, 30.6mmol) and sodium hydroxide (1Og, 250mmol) in water (100ml) was heated under reflux for 4 days, then allowed to cool to room temperature and stand for 6 days. The stirred reaction mixture was then treated with acetic acid to pH 7 and the resulting precipitate filtered off, washed with water and dried under vacuum to leave a white solid. This material was suspended in water (200ml), adjusted to pH 2 by addition of cone HCI acid and then stirred vigorously for 2 hours. The remaining solid was filtered off and the filtrate adjusted to pH 7 by addition of cone. NaOH solution producing a precipitate. This mixture was cooled to 70C
References:
WO2009/34061,2009,A1 Location in patent:Page/Page column 44-45
773837-37-9
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3132-99-8
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150174-93-9
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$81.76/0.5g
7440-44-0
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79422-72-3
6 suppliers
inquiry
150174-93-9
18 suppliers
$81.76/0.5g