ALLYLETHYLAMINE synthesis
- Product Name:ALLYLETHYLAMINE
- CAS Number:2424-02-4
- Molecular formula:C5H11N
- Molecular Weight:85.15
75-04-7
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107-05-1
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2424-02-4
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3454-10-2
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Yield:2424-02-4 62%
Reaction Conditions:
in water at 20;
Steps:
Allyl(methyl)amine (1a) and methyl(prop-2-ynyl)amine (1b) (general procedure).
General procedure: Allyl chloride or propargyl bromide in a 4 : 1 molar ratio, respectively, was added in portions from a dropping funnel to a 40% aqueous solution of methylamine at room temperature under constant stirring. The solution was stirred at room temperature for 3-4 h and then carefully acidified with HCl. The mixture was then treated with ether to extract unreacted halide. The amine hydrochloride solution was concentrated under reduced pressure and then transferred to a Favorsky flask equipped with aLiebig condenser and a receiver cooled by ice. A highly concentrated KOH solution was slowly added through a dropping funnel to a heated reaction mixture. The fractions boiling at 40-70°C (1a) and 45-92°C (1b) were collected, dried over MgSO4, and placed into a refrigerator. A day after, the amine layer was decanted, dried over MgSO4, and distilled from a Favorsky flask.
References:
Ayrapetyan, L. V.;Chukhajian, E. O.;Mkrtchyan, H. S.;Panosyan, H. A. [Russian Journal of Organic Chemistry,2020,vol. 56,# 2,p. 353 - 355][Zh. Org. Khim.,2020,vol. 56,# 2,p. 319 - 322,4]
55487-51-9
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2424-02-4
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199595-92-1
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42055-16-3
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2424-02-4
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40171-86-6
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75-04-7
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123-38-6
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