ChemicalBook CAS DataBase List 4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE

4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE synthesis

4synthesis methods

Product Name:4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE
CAS Number:97817-23-7
Molecular formula:C6H9N3S
Molecular Weight:155.22

124458-10-2
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$72.00/100mg

4,5,6,7-TETRAHYDRO-THIAZOLO[5,4-C]PYRIDIN-2-YLAMINE

97817-23-7
60 suppliers
$55.00/100mg

Yield:97817-23-7 91%

Reaction Conditions:

with formaldehyd;acetic acid in methanol;

Steps:

D.6 2-Amino-4-(2-aminoethyl)thiazole

6. 2-Amino-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine A solution of 2-amino-4-(2-aminoethyl)thiazole (1.57 g, 11.0 mmol) in methanol (120 ml) was treated with acetic acid (0.15 ml, 2.6 mmol) and formaldehyde (0.89 ml of a 37% aqueous solution, 11 mmol). After ten minutes, the reaction mixture was concentrated in vacuo and subjected to column chromatography (eluant: 95:4:1 chloroform:methanol:concentrated ammonium hydroxide). The product was obtained as a white solid, m.p. 169°-173° (1.547 g, 10.0 mmol, 91% yield). ¹ H NMR (DMSO-d₆): 6.64 (s, 2H), 3.59 (s, 2H), 2.87 (t, J=6 Hz, 2H), 2.33 (bt, 2H).

References:

US5037834,1991,A