ChemicalBook CAS DataBase List [1,2,4]Triazolo[1,5-a]pyridine, 7-(2-methyl-4-nitrophenoxy)-

[1,2,4]Triazolo[1,5-a]pyridine, 7-(2-methyl-4-nitrophenoxy)- synthesis

6synthesis methods

Product Name:[1,2,4]Triazolo[1,5-a]pyridine, 7-(2-methyl-4-nitrophenoxy)-
CAS Number:937263-44-0
Molecular formula:C13H10N4O3
Molecular Weight:270.24

1033810-70-6 Synthesis

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455-88-9 Synthesis

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[1,2,4]Triazolo[1,5-a]pyridine, 7-(2-methyl-4-nitrophenoxy)-

937263-44-0
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Yield:937263-44-0 87%

Reaction Conditions:

with caesium carbonate in dimethyl sulfoxide at 80; for 3 h;

Steps:

1.1 Step 1. Synthesis of 7-(2-methyl-4-nitrophenoxy)-[ 1, 2, 4itriazolo[f 5-aJpyridine.

The mixture of l-fluoro-2-methyl-4-nitrobenzene (96 mg, 0.617 mmol), [l,2,4]triazolo[l,5-a]pyridin-7-ol (100 mg, 0.740 mmol) aid cesium carbonate (482 mg, 1.48 mmol) in dimethyl sulfoxide (2.5 ml) was stirred at 80 °C for 3 hr. The resulting mixture was poured into ice water and the precipitate was filtered and dried using blowing nitrogen gas to give 4-([l,2,4]triazolo[l,5-a]pyridin-7-yloxy)-3-methylaniline as a brown solid (145 mg, 87 %).

References:

WO2019/241715,2019,A1 Location in patent:Paragraph 00339

99-53-6 Synthesis