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ChemicalBook CAS DataBase List 5-(3,4-DICHLORO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID
876710-49-5

5-(3,4-DICHLORO-PHENYL)-ISOXAZOLE-3-CARBOXYLIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: sodium methylate / tetrahydrofuran / 8 h / 20 °C
2: hydroxylamine hydrochloride / methanol / 3 h / Reflux
3: sodium hydroxide / tetrahydrofuran / 1 h / 60 °C

References:

Kamal, Ahmed;Tamboli, Jaki R.;Vishnuvardhan;Adil;Nayak, V. Lakshma;Ramakrishna [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 1,p. 273 - 280]

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