4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE synthesis
- Product Name:4-CHLORO-2-METHYL-5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDINE
- CAS Number:81765-97-1
- Molecular formula:C11H11ClN2S
- Molecular Weight:238.74
![2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one](/CAS/20180528/GIF/19819-15-9.gif)
19819-15-9
10 suppliers
inquiry
81765-97-1
41 suppliers
$44.00/250mg
Yield:81765-97-1 97%
Reaction Conditions:
with trichlorophosphate at 110; for 3 h;
Steps:
3 Intermediate 4
Intermediate 3 (0.82 mmol) and 5 mL of POCl3 were added into a 100 mL evaporating flask. The reaction solution was refluxed under stirring at 110° C. for 3 h, then cooled to room temperature and evaporated to dryness by rotary evaporation under reduced pressure. The residue was dissolved in an appropriate amount of ethyl acetate and adjusted to be alkaline by adding a saturated aqueous NaHCO3 solution. Then the mixture was extracted with ethyl acetate, washed with a saturated NaCl aqueous solution, and the organic layer was evaporated to dryness by rotary evaporation to obtain an Intermediate 4 (white solid, 97% yield), which was directly put into next reaction without purification.
References:
US2022/227782,2022,A1 Location in patent:Paragraph 0059
19819-15-9
10 suppliers
inquiry
81765-97-1
41 suppliers
$44.00/250mg
![ETHYL 2-AMINO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHENE-3-CARBOXYLATE](/CAS/GIF/4506-71-2.gif)
4506-71-2
205 suppliers
$6.00/1g
81765-97-1
41 suppliers
$44.00/250mg
108-94-1
570 suppliers
$12.00/50g
81765-97-1
41 suppliers
$44.00/250mg