ChemicalBook CAS DataBase List 5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine

5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine synthesis

6synthesis methods

Product Name:5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine
CAS Number:817623-11-3
Molecular formula:C31H30N2O7
Molecular Weight:542.59

433733-92-7 Synthesis

433733-92-7
27 suppliers
inquiry

40615-36-9 Synthesis

40615-36-9
549 suppliers
$5.00/1g

5'-O-(4,4'-Dimethoxytrityl)-5-methyl-2,2'-anhydro-D-uridine

817623-11-3
13 suppliers
inquiry

Yield:817623-11-3 97.8%

Reaction Conditions:

with pyridine;dmap at 0 - 5; for 1.5 h;

Steps:

24

To a previously cooled (0-5° C.) mixture of 2,2'-anhydro-1--D-arabinofuranosyl)-thymine 1 (2.40 g, 10.0 mmol) and DMAP (111 mg, 0.9 mmol) in anhydrous pyridine (15 mL), was added 4,4'-dimethoxytrityl chloride (3.56 g, 10.5 mmol) portionwise over a period of 3 minutes. The resulting mixture was kept stirring at 0-5° C. under argon and after 1.5 h, t.l.c. analysis (silica plate, 1:9 methanol:dichloromethane) indicated no remaining starting material. The reaction mixture was concentrated in vacuo at 45° C. The residue was taken into dichloromethane (50 mL) and sat. sodium bicarbonate solution (20 mL). After stirring at room temperature for 10 minutes, the layers were separated and the organic layer was washed with distilled water (2×20 mL) and dried with anhydrous sodium sulfate. The reaction mixture was concentrated in vacuo at 50° C. and residue was co-evaporated with toluene (2×10 mL). The resulting crude residue was triturated with dichloromethane (5 mL) and TBME (25 mL). After stirring at room temperature for 1 hour, the solid was collected by filtration under reduced pressure and washed with TBME (15 mL). The yellow solid was dried under vacuum affording 2,2'-anhydro-1-(5-O-dimethoxytrityl--D-arabinofuranosyl)thymine 2 (5.3 g, 97.8% yield, 91% AUC (area under curve) by HPLC analysis).

References:

US2005/59632,2005,A1 Location in patent:Page/Page column 41; 42

22423-26-3 Synthesis