午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频

Welcome to chemicalbook!
Chinese English Japanese Germany Korea
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

ChemicalBook CAS DataBase List 8-Chloro-2-Methyl-1,5-naphthyridine
911389-21-4

8-Chloro-2-Methyl-1,5-naphthyridine synthesis

1synthesis methods
-

Yield: 67%

Reaction Conditions:

Stage #1:6-methyl-[1,5]naphthyridin-4-ol with trichlorophosphate for 2 h;Heating / reflux;
Stage #2: with ammonia in water

Steps:

20
8-Chloro-2-methyl-[1,5]naphthyridine; The suspension of 6-methyl-[1,5]naphthyridin-4-ol (1.60 g, 9.99 mmol) in POCl3 (25 mL) was heated under refluxing for 2 hrs. After cooling to room temperature, the reaction mixture was quenched with ice water and basified with NH4OH followed by extraction with AcOEt. The organic layer was washed with brine and dried over NaSO4, and concentrated to give 8-chloro-2-methyl-[1,5]naphthyridine as a brown solid (1.2 g, 67%). HR-MS-EI (+) m/e calcd for C9H7N2Cl (M+) 178.0298, found 178.0297.

References:

Location in patent:Page/Page column 9; 19

8-Chloro-2-Methyl-1,5-naphthyridine Related Search: