7-Fluoro-4-quinazolone synthesis
- Product Name:7-Fluoro-4-quinazolone
- CAS Number:16499-57-3
- Molecular formula:C8H5FN2O
- Molecular Weight:164.14
446-32-2
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3473-63-0
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16499-57-3
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$6.00/250mg
Yield:16499-57-3 99%
Reaction Conditions:
in ethanol; for 24 h;
Steps:
7-fluoroquinazoline-4(3H)-one
7-fluoroquinazoline-4(3H)-one 2-amino-4-fluorobenzoic acid (13.5 g, 87 mmol) was dissolved in ethanol (15 mL), added to formamidine acetate (18.1 g, 174 mmol) and refluxed for 1 d. Water (250 mL) was then added, the precipitated product was filtered out and washed with 70% ethanol. (Yield: 14.2 g, 99%). [Alternatively, the conversion was conducted in several cases (e.g. in the production of exemplary compound 881) without solvent, with formamide at 175° C.]
References:
US2009/69320,2009,A1 Location in patent:Page/Page column 67
446-32-2
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$6.00/5g
16499-57-3
240 suppliers
$6.00/250mg
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117324-05-7
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16499-57-3
240 suppliers
$6.00/250mg