ChemicalBook CAS DataBase List 7-CHLORO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE

7-CHLORO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE synthesis

4synthesis methods

Product Name:7-CHLORO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE
CAS Number:66367-05-3
Molecular formula:C8H7ClN2O
Molecular Weight:182.61

66367-04-2
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7-CHLORO-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE

66367-05-3
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$125.00/1g

Yield:66367-05-3 68.9%

Reaction Conditions:

with hydrogenchloride;tin in ethanol;water; for 2 h;Reflux;

Steps:

N-4-Chloro-2-nitrophenyl glycine (1) (9 mmol) and tin powder (3.2g, 27 mmol) was mixed in anhydrous EtOH (30 ml). Concentrated HCl (6 ml) was added dropwise. Then the mixture was refluxed for 2 hr and cooled to room temp. After addition of water (5 ml), the precipitated product was filtered and washed with H2O. The product (2) was obtained as solid with the yield of 68.9%.

References:

Ye, Fei;Liu, Jing;Fu, Ying;Qu, Li-Hua;Zhao, Qin-Shan [Indian Journal of Heterocyclic Chemistry,2014,vol. 23,# 3,p. 233 - 238]