7-Bromo-1H-indazole synthesis
- Product Name:7-Bromo-1H-indazole
- CAS Number:53857-58-2
- Molecular formula:C7H5BrN2
- Molecular Weight:197.03
![Diazene, 1-(2-bromo-6-methylphenyl)-2-[(1,1-dimethylethyl)thio]-](/CAS/20210305/GIF/845751-60-2.gif)
845751-60-2
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53857-58-2
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Yield:53857-58-2 96%
Reaction Conditions:
with potassium tert-butylate in dimethyl sulfoxide at 20; for 2 h;
Steps:
1.4
A solution of (2-bromo-6-methylphenylazo)-t-butylsulfide (2b; 880 mg, 3.06 mmol) in 10 mL dry DMSO was added dropwise to a solution of potassium t-butoxide (3.44 g, 30.6 mmol) in 25 mL dry DMSO under Ar. The reaction mixture was stirred at room temp for 2 hr, then poured into 150 g ice and 150 mL 2 N HCl solution. The mixture was extracted with ether (2?150 mL). The combined ethereal extracts were washed with brine and dried over MgSO4. Evaporation of the solvent afforded 581 mg (96%) of 3 as a beige solid.
References:
US2004/110815,2004,A1 Location in patent:Page/Page column 19
53848-17-2
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53857-58-2
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$7.00/250mg
601-87-6
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53857-58-2
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$7.00/250mg
52414-97-8
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53857-58-2
197 suppliers
$7.00/250mg