6H-dibenzo-(b,d)-pyran-6-one synthesis
- Product Name:6H-dibenzo-(b,d)-pyran-6-one
- CAS Number:2005-10-9
- Molecular formula:C13H8O2
- Molecular Weight:196.2
26260-02-6
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89466-08-0
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2005-10-9
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$48.00/250mg
Yield: 91%
Reaction Conditions:
with palladium diacetate;potassium carbonate;triphenylphosphine in N,N-dimethyl-formamide at 90; for 3 h;Inert atmosphere;Suzuki-Miyaura Coupling;Reagent/catalyst;Temperature;Solvent;
Steps:
General procedure for the one-pot synthesis of benzo[c]chromen-6-ones:
General procedure: The 2-bromoarylcarboxaldehyde (1 mmol), 2-hydroxyphenylboronic acid (1 mmol), K2CO3 (1 mmol.), PPh3 (0.25 mmol) were taken in a two-necked round bottomed flask and flushed with nitrogen gas. Then 3 mL of DMF was added and degassed with N2. The catalyst Pd(OAc)2 (5 mol%) was added to the reaction mixture and heated at 90 °C for 4 h. After completion of the reaction, the reaction mixture was allowed to cool to room temperature, diluted with water and extracted with ethyl acetate (3 × 20 mL). The combined organic layer was dried over Na2SO4 and evaporated under reduced pressure. The crude product was purified by column chromatography using silica gel (60-120 mesh) and hexane/EtOAc as eluent.
References:
Singha, Raju;Roy, Soumyabrata;Nandi, Sukla;Ray, Priyanka;Ray, Jayanta K. [Tetrahedron Letters,2013,vol. 54,# 7,p. 657 - 660] Location in patent:supporting information
![[1,1'-Biphenyl]-2-carboxylic acid, 2'-bromo-, methyl ester](/CAS/20210305/GIF/1000071-27-1.gif)
1000071-27-1
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2005-10-9
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486-25-9
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2005-10-9
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947-84-2
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2005-10-9
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69200-16-4
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2005-10-9
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$48.00/250mg