ChemicalBook CAS DataBase List Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate synthesis

8synthesis methods

Product Name:Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
CAS Number:6386-38-5
Molecular formula:C18H28O3
Molecular Weight:292.41

67-56-1 Synthesis

67-56-1
757 suppliers
$7.29/5ml-f

20170-32-5 Synthesis

3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic acid

20170-32-5
159 suppliers
$13.00/5g

Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate

6386-38-5
175 suppliers
$13.00/10g

Yield:6386-38-5 90%

Reaction Conditions:

with sulfuric acid for 16 h;Reflux;

Steps:

Typical procedure for synthesis of methyl esters
General procedure: According to a literature protocol.[1] Propanoic acid derivative (10 g) was dissolved inmethanol (80 ml) and H2SO4 (700μl, 6 mmol) added. The resulting solution was refluxed for16 h and then allowed to cool to room temperature. The reaction mixture was reduced todryness and re-dissolved in ethyl acetate (20 ml). The organic phase was washed withsaturated aqueous sodium hydrogen carbonate (10 ml), brine (10 ml) and dried over MgSO4.Removal of the solvent gave the desired methyl ester. (Note: column chromatography is oftennot required for the methyl ester starting materials).

References:

Jones, Kevin M.;Hillringhaus, Tim;Klussmann, Martin [Tetrahedron Letters,2013,vol. 54,# 25,p. 3294 - 3297] Location in patent:supporting information

FullText