1-PIPERAZINECARBOXYLIC ACID, 4-(5-BROMOPYRAZINYL)-, 1,1-DIMETHYLETHYL ESTER synthesis
- Product Name:1-PIPERAZINECARBOXYLIC ACID, 4-(5-BROMOPYRAZINYL)-, 1,1-DIMETHYLETHYL ESTER
- CAS Number:622386-08-7
- Molecular formula:C13H19BrN4O2
- Molecular Weight:343.22
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Yield:622386-08-7 97%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in 1-methyl-pyrrolidin-2-one at 110; for 2 h;
Steps:
13.1 Step 1: Synthesis of tert-bulyl 4-(5-bromopyrazin-2-yl)piperazine-] -carboxylate
A mixture of 2,5-dibromopyrazine (2 g, 8.40 mmol), tert-butyl piperazine-1-carboxylate (1.86 g, 10.0 mmol) and DIPEA (1.62 g, 12.6 mmol) in NMP (40 mL) was stirred at 110 °C for 2 h. Diluted with ethyl acetate, washed with water and brine, dried over Na2SO4, and concentratedto give the title product (2.8 g, yield 97%). MS (ES+) C13H19BrN4O2 requires: 342, found: 343 [M+H] .
References:
WO2017/181117,2017,A1 Location in patent:Page/Page column 252
622386-07-6
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622386-08-7
17 suppliers
inquiry
57260-71-6
739 suppliers
$5.00/5g
622386-08-7
17 suppliers
inquiry