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ChemicalBook CAS DataBase List 4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester
620611-27-0

4-Aminomethyl-4-fluoro-piperidine-1-carboxylic acid tert-butyl ester synthesis

5synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: pyridine hydrofluoride / dichloromethane / -10 - 20 °C
2: pyridine / 0 - 20 °C
3: N,N-dimethyl-formamide / 12 h / 150 °C
4: ethanolamine / 2.5 h / 60 °C

References:

AC Immune, S.A. US2011/256064, 2011, A1

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