6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one synthesis
- Product Name:6-Hydroxy-7-methoxy-3,4-dihydroquinazolin-4-one
- CAS Number:179688-52-9
- Molecular formula:C9H8N2O3
- Molecular Weight:192.17
13794-72-4
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179688-52-9
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Yield:179688-52-9 94%
Reaction Conditions:
with methanesulfonic acid;L-methionine at 100; for 22 h;
Steps:
1.1-2
( 1 -2) 6-hydroxy-7-methoxyquinazolin-4(3H)-one; 3.06 g of the compound obtained in (1-1) was diluted with 20 mi of methanesulfonic acid. 2.66 g of /--methionine was added to the resulting solution and stirred at 100 °C for 22 hours. Ice was added to the reaction mixture and neutralized with 40% aqueous sodium hydroxide to induce the crystallization of the product. The solid was filtered under a reduced pressure, washed with water, and air-dried to obtain the title compound (2.67 g, 94%).1H-NMR (300MHz, DMSO-d6) δ 11.94 (s, IH), 9.81 (s, IH), 7.92 (_?, IH), 7.39 (s, IH), 7.11 (s, IH), 3.91 (s, 3H).
References:
HANMI PHARM. CO., LTD. WO2008/150118, 2008, A2 Location in patent:Page/Page column 21
884344-38-1
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179688-52-9
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