6-carboxyhexyl triphenylphosphonium bromide synthesis
- Product Name:6-carboxyhexyl triphenylphosphonium bromide
- CAS Number:50889-30-0
- Molecular formula:C25H28BrO2P
- Molecular Weight:471.3664
Yield: 86%
Reaction Conditions:
in acetonitrile for 18 h;Heating / reflux;
Steps:
3
Intermediate 3.1; 6-Carboxyhexyl(triphenyl)phosphonium bromide; A solution of 6-bromohexanoic acid (18 mmol, 3.50 g) and triphenylphosphine (18 mmol, 4.71 g) in acetonitrile (18 mL) was refluxed for 18 h. The reaction mixture was then cooled down, the off-white solid formed filtered. Flash chromatography over silica gel (EtOAc then MeOH) afforded the product as a white solid (1.08 g, 86%).
References:
APPLIED RESEARCH SYSTEMS ARS HOLDING N.V. WO2006/61366, 2006, A1 Location in patent:Page/Page column 67
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