6,8-DIMETHYL-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID synthesis
- Product Name:6,8-DIMETHYL-2-PHENYLQUINOLINE-4-CARBOXYLIC ACID
- CAS Number:337496-05-6
- Molecular formula:C18H15NO2
- Molecular Weight:277.32
Yield:-
Reaction Conditions:
with water;potassium hydroxide for 24 h;Heating;
Steps:
General procedure: To a solution of 33% KOH (aqueous, 6.8 mL) in MeOH (15 mL), isatin(A1, 1.00 g, 6.8 mmol) was reacted with 4′-methylacetophenone (B1,0.91 g, 6.8 mmol) at 100 for 24 h. After reaction, the solvent wasevaporated in vacuum, and the residue dissolved in water. Hydrochloricacid was used to adjust the pH to 2, and white solid was precipitated.Suction filtration was used to collect the white solid, which was thenvacuum dried to produce the intermediate C1 (1.20 g, yield 67%).
References:
Liu, Wei;Jia, Hairui;Guan, Minghao;Cui, Minxuan;Lan, Zhuxuan;He, Youyou;Guo, Zhongjie;Jiang, Ru;Dong, Guoqiang;Wang, Shengzheng [Bioorganic Chemistry,2022,vol. 118,art. no. 105486]
100-52-7
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337496-05-6
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