6-(2-Hydroxyphenyl)-nicotinic acid synthesis
- Product Name:6-(2-Hydroxyphenyl)-nicotinic acid
- CAS Number:31676-66-1
- Molecular formula:C12H8ClNO2
- Molecular Weight:233.65
5326-23-8
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1679-18-1
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31676-66-1
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$291.00/250mg
Yield:-
Reaction Conditions:
Stage #1: 6-Chloro-3-pyridinecarboxylic acidwith tritylchloride-polystyrene resin;N-ethyl-N,N-diisopropylamine in dichloromethane;N,N-dimethyl-formamide at 20; for 18 h;
Stage #2: 4-Chlorophenylboronic acidwith potassium phosphate;phenyl-phospha-adamantane;tris(dibenzylideneacetone)dipalladium(0) chloroform complex in tetrahydrofuran;water at 20; for 15 h;solid-phase Suzuki coupling;
Stage #3: with trifluoroacetic acid in dichloromethane at 20; for 1.5 h;Further stages.;
References:
Ohnmacht, Stephan A.;Brenstrum, Tim;Bleicher, Konrad H.;McNulty, James;Capretta, Alfredo [Tetrahedron Letters,2004,vol. 45,# 29,p. 5661 - 5663]