CHLOROXYLENOL RELATED COMPOUND A (25 MG) (2- CHLORO-3,5-DIMETHYLPHENOL) synthesis
- Product Name:CHLOROXYLENOL RELATED COMPOUND A (25 MG) (2- CHLORO-3,5-DIMETHYLPHENOL)
- CAS Number:5538-41-0
- Molecular formula:C8H9ClO
- Molecular Weight:156.61
108-68-9
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88-04-0
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133-53-9
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5538-41-0
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$75.00/100mg
Yield: 75 %Chromat. ， 10 %Chromat. ， 9 %Chromat.
Reaction Conditions:
with iron(III) chloride;sulfuryl dichloride;1,3-bis(methylthio)propane in dichloromethane at 20; for 4 h;regioselective reaction;Reagent/catalyst;
Steps:
4.2. Typical experimental procedure for the chlorination of m-xylenol
General procedure: Freshly distilled sulfuryl chloride (4.66 mL, 57.7mmol) was added slowly over 2 h, via a pressure equalizing dropping funnel, to a solution of m-xylenol (6.1 g, 50 mmol), FeCl3 (25mg, 0.154mmol) and an additive (30 mg) in DCM (25 mL) in a round bottomed flask (50mL). The mixture was stirred at room temperature for a further 2h and the reaction was quenched with water (20mL). The organic components were extracted with ether (3×30 mL). The ether layers were removed, combined and dried over MgSO4. The drying agent was filtered and the solvent was removed under reduced pressure. The crude product was weighed and then analyzed by quantitative GC in the presence of tetradecane as added internal standard.
References:
Smith, Keith;Al-Zuhairi, Ali J.;Elliott, Mark. C.;El-Hiti, Gamal A. [Journal of Sulfur Chemistry,2018,vol. 39,# 6,p. 607 - 621]
108-68-9
340 suppliers
$9.00/5g
5538-41-0
64 suppliers
$75.00/100mg