2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID synthesis
- Product Name:2-METHYL-1,2,3,4-TETRAHYDRO-ISOQUINOLINE-3-CARBOXYLIC ACID
- CAS Number:54329-54-3
- Molecular formula:C11H13NO2
- Molecular Weight:191.23
67123-97-1
133 suppliers
$9.00/1g
54329-54-3
61 suppliers
$18.00/100mg
Yield:54329-54-3 53%
Reaction Conditions:
with hydrogenchloride;formaldehyd in formic acid;water;
Steps:
3 2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid
PREPARATION 3 2-Methyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid A solution of 0.364 g (2.07 mmol) of 3-carboxy-1,2,3,4-tetrahydroisoquinoline in 25 mL of formic acid was combined with 2.5 mL of 37% formaldehyde. The resulting mixture was allowed to reflux for approximately 17 hours. After cooling, the mixture was contentrated under reduced pressure to provide a gum. This gum was dissolved in 3.0 mL of water, adjusted to a pH 2 using hydrochloric acid and then purified using ion-exchange chromatography (Dowex 50x-8, 100 meshcation) to provide 0.21 g of a yellow powder. Yield: 53% 1 H NMR (DMSO-d6): δ2.56 (S, 3H), 3.01 (m, 2H), 3.48 (t, 1H), 3.9 (dd, 2H) 7.05 (m, 1H), 7.13 (m, 3H). MS (FD): m/e 192 (M+2).
References:
US5491166,1996,A
50-00-0
867 suppliers
$10.00/25g
67123-97-1
133 suppliers
$9.00/1g
54329-54-3
61 suppliers
$18.00/100mg