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143-33-9 Synthesis

143-33-9
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$10.00/1g

103788-61-0 Synthesis

4-(CHLOROMETHYL)-5-METHYL-2-PHENYL-1,3-OXAZOLE

103788-61-0
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$149.00/250mg

524959-64-6
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Yield:524959-64-6 92%

Reaction Conditions:

methyl tributylammonium chloride in water;toluene at 80 - 85; for 6 h;

Steps:

1.b

) Reaction of the oxazole chloride1634 g (7.87 mol) of oxazole chloride, 463 g (9.44 mol) of NaCN, 28 g (0.119 mol) of tributylmethylammonium chloride, 4.9 1 of toluene and 0.24 1 of H₂O were introduced into the reactor, and this mixture was heated at 80-85°C while stirring vigorously for 6 h. After the reaction mixture had cooled to 20⁰C, dilute aqueous Na₂CO₃ solution was added and, after phase separation, the organic phase was extracted twice with dilute aqueous Na₂CO₃ solution. The residue after concentration of the organic phase in vacuo was dissolved in diisopropyl ether, filtered through activated carbon and crystallized. 1435 g (7.24 mol, 92%) of the oxazole nitrile were obtained.

References:

WO2006/108491,2006,A1 Location in patent:Page/Page column 7