(3-((4-Methylpiperazin-1-yl)Methyl)phenyl)MethanaMine synthesis
- Product Name:(3-((4-Methylpiperazin-1-yl)Methyl)phenyl)MethanaMine
- CAS Number:515162-19-3
- Molecular formula:C13H21N3
- Molecular Weight:219.33
![3-[(4-METHYLPIPERAZIN-1-YL)METHYL]BENZONITRILE](/CAS/GIF/859850-90-1.gif)
859850-90-1
44 suppliers
inquiry
515162-19-3
37 suppliers
$116.00/500mg
Yield:515162-19-3 85.1%
Reaction Conditions:
with ammonia;hydrogen in methanol at 25; under 775.743 Torr; for 1 h;
Steps:
14.2 The second step: the preparation of (3-((4-methylpiperazin-1-yl)methyl)phenyl)methanamine
The raw material 3-((4-methylpiperazin-1-yl)methyl)benzonitrile (1.50 g, 6.97 mmol, 1.0 eq) was dissolved in methanol (25 mL), and ammonia water (4.55 mL) was added successively at 25°C. g, 36.4 mmol, 5 mL, 28% purity, 5.2 eq) and Raney nickel (597 mg), the reaction solution was replaced with nitrogen three times, hydrogen replaced three times, and then stirred at 25°C under hydrogen atmosphere (15 Psi) for 1 h. TLC (DCM:MeOH=10:1) detected the completion of the reaction, filtered, washed the filter cake with methanol, and concentrated the filtrate to obtain the target compound (1.30 g, 85.1%). used directly in the next step.
References:
WO2022/161420,2022,A1 Location in patent:Page/Page column 64
109-01-3
673 suppliers
$5.00/5G
515162-19-3
37 suppliers
$116.00/500mg
24964-64-5
334 suppliers
$9.00/1g
515162-19-3
37 suppliers
$116.00/500mg
28188-41-2
260 suppliers
$5.00/1g
515162-19-3
37 suppliers
$116.00/500mg