ChemicalBook CAS DataBase List 5-NITROFURFURYL ALCOHOL

5-NITROFURFURYL ALCOHOL synthesis

9synthesis methods

Product Name:5-NITROFURFURYL ALCOHOL
CAS Number:2493-04-1
Molecular formula:C5H5NO4
Molecular Weight:143.1

645-12-5 Synthesis

645-12-5
147 suppliers
$17.00/1g

2493-04-1
52 suppliers
$31.00/250mg

Yield:2493-04-1 98%

Reaction Conditions:

with borane-THF in tetrahydrofuran at 20; for 16 h;Inert atmosphere;Cooling with ice;

Steps:

2 This example provides the synthesis of 2-hydroxymethyl-5-nitrofuran, the method is as follows:
Under the protection of nitrogen, compound 5-nitrofuran-2-carboxylic acid (1.00g, 6.37mmol) was added to dry tetrahydrofuran (12mL), and 1.0M borane tetrahydrofuran solution (19.2mL, 19.2mmol) was slowly added dropwise under ice bath. After the addition is complete, the temperature is raised to room temperature under the protection of nitrogen and stirred for 16 hours.It was quenched by adding methanol 10mL under ice bath, extracted with ethyl acetate (40mL×3), combined the organic phases, washed with saturated sodium bicarbonate solution, water, saturated brine successively, dried over anhydrous sodium sulfate, filtered, and the filtrate was rotary evaporated It was evaporated to dryness and purified to obtain a brown oil, namely 2-hydroxymethyl-5-nitrofuran (0.89 g, yield 98percent).

References:

Anhui Zesheng Technology Co., Ltd.;Li Zhan;Luo Bo;Sun Wenhai;Sun Xiling;Ning Fangxian CN111440141, 2020, A Location in patent:Paragraph 0042-0048

FullText

698-63-5 Synthesis