5-NITRO-2-(4-PYRIDINYL)-1H-BENZIMIDAZOLE synthesis
- Product Name:5-NITRO-2-(4-PYRIDINYL)-1H-BENZIMIDAZOLE
- CAS Number:148533-73-7
- Molecular formula:C12H8N4O2
- Molecular Weight:240.22
Yield: 88%
Reaction Conditions:
with sodium dithionate in N,N-dimethyl-formamide for 3 h;Reflux;
Steps:
3.1 General Procedure for the Synthesis of Compounds 1-27
General procedure: Equimolar mixture of pyridine carboxaldehyde deriva-tives (1 mmol) and sodium metabisulphite (1 mmol) in DMF (10 mL) was stirred for 10 to 15 min, followed by the addi-tion of o-phenylene diamine/2-aminothiophenol (1 mmol) into it and refluxed for 3 h. The progress of the reaction was monitored by TLC. After completion, the reaction mixture was poured into crushed ice, precipitates were formed which were collected by filtration to afford compounds 1-27 in good yields. Recrystallization from methanol yielded pure crystals.
References:
Khan, Momin;Ahmad, Riaz;Rehman, Gauhar;Gul, Naeem;Shah, Sana;Salar, Uzma;Perveen, Shahnaz;Khan, Khalid Mohammed [Letters in drug design and discovery,2019,vol. 16,# 9,p. 984 - 993]
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