5-METHYLISOPHTHALALDEHYDE synthesis
- Product Name:5-METHYLISOPHTHALALDEHYDE
- CAS Number:1805-67-0
- Molecular formula:C9H8O2
- Molecular Weight:148.16
27711-63-3
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Yield:1805-67-0 89%
Reaction Conditions:
with pyridinium chlorochromate in dichloromethane at 0 - 20; for 12 h;
Steps:
5-Methylisophthalaldehyde 3
General procedure: (5-Methyl-1,3-phenylene)dimethanol 2 (1.00 g, 6.62 mmol) and PCC (3.20 g, 15.2 mmol) were dissolvedin CH2Cl2 at 0 °C. The reaction mixture was stirred for 12 h at room temperature, and insoluble materialswere removed with celite filtration. The filtrate was evaporated, and the residue was purified by columnchromatography (CH2Cl2 to AcOEt/hexane 1/2) to yield 5-methylisophthalaldehyde 3 (873 mg, 89%) as awhite-colored amorphous mass. Analytical data were identical to those reported in the literature.
References:
Hashimoto, Makoto;Murai, Yuta;Tachrim, Zetryana Puteri;Yoshida, Takuma [Heterocycles,2021,vol. 104,# 1,p. 167 - 177]
108-67-8
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5779-95-3
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19294-04-3
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