ChemicalBook CAS DataBase List 5-Hydroxy-1-tetralone

5-Hydroxy-1-tetralone synthesis

7synthesis methods

Product Name:5-Hydroxy-1-tetralone
CAS Number:28315-93-7
Molecular formula:C10H10O2
Molecular Weight:162.19

83-56-7
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$9.00/25g

28315-93-7
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$7.00/250mg

Yield:28315-93-7 83.3%

Reaction Conditions:

with palladium on activated charcoal;ammonium formate in water;butan-1-ol at 120; for 3 h;Further stages;Temperature;Solvent;Reagent/catalyst;

Steps:

2 Example 2
Mixing 32 g of 1,5-dihydroxynaphthalene, 8 g of water, 152 g of n-butanol, 3.2 g of palladium on carbon and 12.6 g of ammonium formate,The reaction was heated to 120 ° C under normal pressure for 3 h, and 12 g of sodium hydroxide was added to the obtained system.Stir and heat filtration, and adjust the pH of the obtained filtrate to 3 with industrial hydrochloric acid having a mass concentration of 31%.After the solid was precipitated, it was suction filtered, and the obtained cake was recrystallized from methanol and water (volume ratio of methanol to water: 4:1).Drying in vacuo gave 27.0 g of 5-hydroxy-1-tetralone.The liquid phase purity is greater than 99% and the yield is 83.3%.

References:

Hangzhou Normal University;Hangzhou Lupu Biological Technology Co., Ltd.;Xu Weiming;Zhang Pengfei;Feng Dongxiang;Tao Lianzhi CN109160882, 2019, A Location in patent:Paragraph 0041-0043-0044; 0048-0049; 0051-0052; 0054-0055

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33892-75-0 Synthesis