5-ethyl-2-hydroxy-3-methylcyclopent-2-en-1-one synthesis
- Product Name:5-ethyl-2-hydroxy-3-methylcyclopent-2-en-1-one
- CAS Number:53263-58-4
- Molecular formula:C8H12O2
- Molecular Weight:140.18
127663-18-7
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Yield:53263-58-4 9.09 g (78.2%)
Reaction Conditions:
with hydrogenchloride
Steps:
6.b EXAMPLE 6
(b) 12.8 g (83 mmol) of crude 5 -ethyl-2-methoxy-3-methyl-2-cyclopenten-1-one are held at reflux temperature for 2 hours with 128 g of 5N hydrochloric acid. The cooled reaction mixture is extracted 3 times with 100 ml of CH2 Cl2. The combined phases are dried over magnesium sulphate and concentrated on a rotary evaporator. The crude product is distilled at 47°-48° C./0.03 mbar and yields 9.09 g (78.2%) of a mixture of 5-ethyl-2-hydroxy-3-methyl-2-cyclopenten-1-one (isomer A) and 3-ethyl-2-hydroxy-5-methyl-2-cyclopenten-1-one (isomer B) in the ratio of about 7:3, content (GC): isomer A 70.2%, isomer B 28.8%.
References:
US4892966,1990,A
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