5-chloro-3-hydroxyisothiazole synthesis

2synthesis methods

Product Name:5-chloro-3-hydroxyisothiazole
CAS Number:25629-58-7
Molecular formula:C3H2ClNOS
Molecular Weight:135.57

5-chloro-3-hydroxyisothiazole can be synthesized from 3,3'-disulfanediyldipropionic acid and Thionyl chloride in three steps. In particular, in the last step, 5-chloro isothiazolone derivatives (5-chloro-3-hydroxyisothiazole) were the predominant products when the ratio of sulfuryl chloride/amide was 3:1 while with the relevant ratio of 1:1, the 5-unsubstituted analogs were the predominant products[1].

3-[(3-AMINO-3-OXOPROPYL)DITHIO]PROPANAMIDE

1002-19-3
48 suppliers
$75.00/100mg

25629-58-7
67 suppliers
$45.00/100mg

1003-07-2 Synthesis

1003-07-2
118 suppliers
$35.00/100mg

Yield:25629-58-7 5% ，1003-07-2 10%

Reaction Conditions:

with sulfuryl dichloride in dichloromethane; for 16 h;Ambient temperature;

References:

Beeley, Nigel R. A.;Harwood, Laurence M.;Hedger, Paul C. [Journal of the Chemical Society. Perkin transactions I,1994,# 16,p. 2245 - 2252]

1002-19-3
48 suppliers
$75.00/100mg

25629-58-7
67 suppliers
$45.00/100mg

References