ChemicalBook CAS DataBase List 5-BROMOMETHYL-3-(4-FLUORO-PHENYL)-ISOXAZOLE

5-BROMOMETHYL-3-(4-FLUORO-PHENYL)-ISOXAZOLE synthesis

5synthesis methods

Product Name:5-BROMOMETHYL-3-(4-FLUORO-PHENYL)-ISOXAZOLE
CAS Number:5262-25-9
Molecular formula:C10H7BrFNO
Molecular Weight:256.07

42202-95-9
45 suppliers
$14.00/250mg

106-96-7 Synthesis

106-96-7
335 suppliers
$31.00/25g

5-BROMOMETHYL-3-(4-FLUORO-PHENYL)-ISOXAZOLE

5262-25-9
24 suppliers
$200.00/1g

Yield:5262-25-9 75%

Reaction Conditions:

with sodium hydrogencarbonate in dichloromethane;water at 0; for 24 h;

Steps:

4.2. General procedure for the synthesis of 3-aryl-5-(bromomethyl)isoxazoles 3

General procedure: Compounds 3 were prepared according to slightly modified published procedure [15]. A mixture of propargyl bromide (3-3.5 mmol), saturated aq. NaHCO₃ (2 mL) and DCM (1-2 mL) was added dropwise to the solution of benzohydroximinoyl chloride 2 (1 mmol) in dichloromethane (DCM) (1-2 mL) at 0 °C. The reaction mixture was stirred for 1 d (TLC control, light petroleum/ethyl acetate 10:1 (v/v)). Then the organic layer was separated, the inorganic layer was extracted with DCM, the combined organic phase was dried (Na₂SO₄) and concentrated under reduced pressure. The resulted solid was crystallized from hexanes or purified by column chromatography on silica gel with light petroleum/ethyl acetate (8:1, v/v) as an eluent.

References:

Serebryannikova, Anna V.;Galenko, Ekaterina E.;Novikov, Mikhail S.;Khlebnikov, Alexander F. [Tetrahedron,2021,vol. 88,art. no. 132153]

206055-89-2 Synthesis