(5-BROMO-PYRIMIDIN-2-YL)-PHENYL-AMINE synthesis
- Product Name:(5-BROMO-PYRIMIDIN-2-YL)-PHENYL-AMINE
- CAS Number:886365-88-4
- Molecular formula:C10H8BrN3
- Molecular Weight:250.09
32779-36-5
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$5.00/5g
62-53-3
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886365-88-4
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$110.37/0.5g
Yield: 70%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in butan-1-ol at 110 - 120;
Steps:
2.1 Step 1:
Step 1: To a solution of 5-bromo-2-chloropyrimidine (2.3 g, 11.9 mmol) and aniline (1.5 mL, 16.1 mmol) in n-BuOH (20 mL) was added DIEA (2 mL, 12,8 mmol). The mixture was stirred at 110-120 °C overnight, then cooled to rt and concentrated to dryness to afford 5- bromo-N-phenylpyrimidin-2-amine as a brown solid (2.0 g, 70%).
References:
PLEXXIKON INC.;HOLLADAY, Mark W.;LIU, Gang WO2017/19804, 2017, A2 Location in patent:Paragraph 0290