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ChemicalBook CAS DataBase List 5-Bromo-4-methoxy-6-methyl-2-pyrimidinamine
7749-55-5

5-Bromo-4-methoxy-6-methyl-2-pyrimidinamine synthesis

1synthesis methods
-

Yield:-

Reaction Conditions:

with N-Bromosuccinimide in acetonitrile at 20;Inert atmosphere;

Steps:

Intermediate B12: (5-chloro-4.6-dimethoxv-pvrimidin-2-vDamine

General procedure: To a stirred solution of (4,6-dimethoxypyrimidin-2-yl)amine (100 mg, 0.632 mmol, CAS: 36315-01-2) in acetonitrile (2 mL) was added N-chlorosuccinimide (109.65 mg, 0.821 mmol) at room temperature. The reaction mixture was stirred at room temperature and the obtained light yellow solution was diluted with EtOAc and washed with water. The organic layer was dried over sodium sulfate, filtered and concentrated in vacuo. The residue was purified by flash chromatography over silica gel using a gradient ethylacetate/heptane 0-50% to provide the title compound as an off-white solid (87 mg, 71 % yield).

References:

WO2022/180136,2022,A1 Location in patent:Page/Page column 88; 134-135; 142

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