5-Bromo-3-cyano-2-hydroxypyridine synthesis
- Product Name:5-Bromo-3-cyano-2-hydroxypyridine
- CAS Number:405224-22-8
- Molecular formula:C6H3BrN2O
- Molecular Weight:199
20577-27-9
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Yield:405224-22-8 88%
Reaction Conditions:
Stage #1: pyrid-2-one-3-carbonitrilewith acetic acid at 130;
Stage #2: with bromine for 3 h;
Steps:
1.2 Step 2: 5-bromo-2-oxo-1,2-dihydropyridine-3-carbonitrile
Acetic acid (34 ml) was added to 2-oxo-1,2-dihydropyridine-3-carbonitrile (6.28 g, 0.052 mol) and the mixture was heated to 130°C. When the solid was dissolved, bromine (12.5 g, 0.078 mol) was added slowly and stirred at the same temperature for 3 hours.After the reaction solution was cooled to room temperature, dichloromethane and water were added. The organic layer was separated and the aqueous layer was washed with dichloromethane. The organic layer was collected, washed with brine, dried over anhydrous sodium sulfate and concentrated to give the desired compound (9.11 g, 88% yield) as a yellow solid.
References:
KR101936851,2019,B1 Location in patent:Paragraph 0173; 0181-0184
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