5-Bromo-2-(dimethylamino)pyridine synthesis
- Product Name:5-Bromo-2-(dimethylamino)pyridine
- CAS Number:26163-07-5
- Molecular formula:C7H9BrN2
- Molecular Weight:201.06
Yield:26163-07-5 512 mg
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 90; for 12 h;
Steps:
38.1 Step 1: Preparation of 5-bromo-N,N-lutidine-2-amine (compound 36b)
Compound 36a (650 mg, 3.38 mmol), dimethylamine hydrochloride (550.86 mg, 6.76 mmol) and potassium carbonate (1.4 g, 10.13 mmol) were added to DMF (10.0 mL) and reacted at 90°C for 12 hours.After the reaction, 200 mL of water was added, extracted with EA, the organic phase was dried over anhydrous sodium sulfate, filtered, concentrated, and separated and purified by silica gel column chromatography (DCM/MeOH=10/1) to obtain compound 36b (512 mg).
References:
WO2022/89219,2022,A1 Location in patent:Page/Page column 46
766-11-0
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26163-07-5
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