ChemicalBook CAS DataBase List 5-BROMO-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-THIONE

5-BROMO-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-THIONE synthesis

7synthesis methods

Product Name:5-BROMO-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-THIONE
CAS Number:68468-39-3
Molecular formula:C7H5BrN2S
Molecular Weight:229.1

75-09-2 Synthesis

75-09-2
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1575-37-7
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5-BROMO-1,3-DIHYDRO-2H-BENZIMIDAZOL-2-THIONE

68468-39-3
45 suppliers
$197.00/1g

Yield:68468-39-3 97 %

Reaction Conditions:

with sulphur in dimethyl sulfoxide at 80;Inert atmosphere;

Steps:

3

Add 128mg (4mmol) of elemental sulfur M1, 187mg (1mmol) of 4-bromo-o-phenylenediamine M5 and 290mg (5mmol) of potassium fluoride into a 10mL polymerization tube, vacuum and change nitrogen three times, and inject 2mL of dimethyl Sulfoxide and 154 μL (2.4 mmol) of dichloromethane M2 were heated to 80 ° C and stirred for 3 hours under airtight conditions; after the reaction was completed, 10 mL of ethyl acetate and 10 mL of water were added, extracted three times, and then the organic layer was collected and dried. Silica gel chromatography was used for separation and purification with a mixed eluent with a volume ratio of petroleum ether and ethyl acetate of 5:1, and then dried to obtain thiourea Compound3 as a white solid. It was determined that the yield of thiourea Compound 3 in this example was 97%.

References:

CN115536563,2022,A Location in patent:Paragraph 0088-0094