5,7-DICHLORO-2-METHYLQUINOLINE synthesis
- Product Name:5,7-DICHLORO-2-METHYLQUINOLINE
- CAS Number:26933-09-5
- Molecular formula:C10H7Cl2N
- Molecular Weight:212.08
75-07-0
424 suppliers
$14.00/5mL
626-43-7
326 suppliers
$10.00/1g
26933-09-5
23 suppliers
$45.00/50mg
Yield:26933-09-5 69%
Reaction Conditions:
with hydrogenchloride in lithium hydroxide monohydrate at 0 - 75; for 4.25 h;
Steps:
1 2-methyl-5,7-dichloro-quinoline(1)
Under constant stirring at 0 °C, to a solution of 3,5-dichloroaniline (3.24 g, 20 mmol)concentrated hydrochloric acid solution (12 mL)35 wt.% aqueous solution of acetaldehyde (12.8 mL, 80 mmol) was added dropwise. The reaction mixture was stirred at 0 °C for 15 minutes and then gradually warmed to 75 °C. And reacted at this temperature for 4 hours. The reaction was cooled to room temperature, poured into ice water, 25% aqueous ammonia solution was added dropwise and made alkaline,Extract with dichloromethane three times.The organic phase was separated, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure.The crude product was isolated and purified by silica gel column chromatography (ethyl acetate / petroleum ether, 1: 20) to obtain 2.93 g of the compound 1 as a pale yellow solid in a yield of 69%.
References:
CN105949120,2016,A Location in patent:Paragraph 0055; 0056; 0057
109-92-2
279 suppliers
$19.00/25mL
626-43-7
326 suppliers
$10.00/1g
26933-09-5
23 suppliers
$45.00/50mg
626-43-7
326 suppliers
$10.00/1g
123-73-9
226 suppliers
$40.00/5g
26933-09-5
23 suppliers
$45.00/50mg