5-(4-ACETYL-PHENYL)-FURAN-2-CARBALDEHYDE synthesis
- Product Name:5-(4-ACETYL-PHENYL)-FURAN-2-CARBALDEHYDE
- CAS Number:57268-39-0
- Molecular formula:C13H10O3
- Molecular Weight:214.22
2689-65-8
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Yield:57268-39-0 187 mg
Reaction Conditions:
Stage #1: 4-Iodoacetophenonewith 1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone;indium(III) chloride;chloro-trimethyl-silane;lithium chloride;zinc in tetrahydrofuran at 25; for 0.5 h;Inert atmosphere;Schlenk technique;Sealed tube;
Stage #2: 5-iodofuran-2-carbaldehydewith 2-dicyclohexylphosphino-2’,6’-dimethoxybiphenyl;palladium diacetate in tetrahydrofuran at 20; for 1 h;Inert atmosphere;Schlenk technique;Sealed tube;Negishi Coupling;
References:
Benischke, Andreas D.;Le Corre, Grégoire;Knochel, Paul [Chemistry - A European Journal,2017,vol. 23,# 4,p. 778 - 782] Location in patent:supporting information
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