5-(2-HYDROXY-BENZYLIDENE)-THIAZOLIDINE-2,4-DIONE synthesis
- Product Name:5-(2-HYDROXY-BENZYLIDENE)-THIAZOLIDINE-2,4-DIONE
- CAS Number:6325-94-6
- Molecular formula:C10H7NO3S
- Molecular Weight:221.23
Yield:6325-94-6 94%
Reaction Conditions:
with thiourea;urea at 110; for 0.25 h;Neat (no solvent);Knoevenagel condensation;
Steps:
General procedure for the synthesis of 5-arylidenethiazolidine-2,4-diones and 5-arylidene-2-thioxothiazolidin-4-ones:
General procedure: A mixture of aldehyde (1 mmol), 2,4-thiazolidinediones/2-thioxothiazolidin-4-ones (1 mmol) using 10 mol % urea/thiourea as catalyst was condensed at 110 °C on oil bath under solvent-free reaction conditions. After completion of the reaction as indicated by TLC, the crude product was cooled, washed with water (10 mL), filtered and recrystallization from ethanol: DMF to afford 3a-ab.
References:
Shah, Sakshi;Singh, Baldev [Bioorganic and Medicinal Chemistry Letters,2012,vol. 22,# 17,p. 5388 - 5391] Location in patent:experimental part
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