2-([(4-CHLOROPHENYL)SULFONYL]AMINO)-3-PHENYLPROPANOIC ACID synthesis
- Product Name:2-([(4-CHLOROPHENYL)SULFONYL]AMINO)-3-PHENYLPROPANOIC ACID
- CAS Number:40279-97-8
- Molecular formula:C15H14ClNO4S
- Molecular Weight:339.79
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Yield:-
Reaction Conditions:
Stage #1: D-(R)-phenylalanine;4-chlorobenzenesulfonyl chloridewith sodium hydrogencarbonate in water at 20;
Stage #2: with hydrogenchloride in water;
Steps:
1.I
To a suspension of D-phenylalanine (100 g, 606mmol) in a solution OfNaHCO3 (103 g, 1.2 mol) in H2O was added /7-chlorophenylsulfonyl chloride (140.6g, 666 mmol). After stirring overnight at room temperature, the reaction mixture was filtered and washed with methylene chloride. The resulting mixture was acidified with HCl and extracted with EtOAc, dried, filtered, and concentrated to give the title compound (109g). M/Z = 339
References:
WO2007/83089,2007,A1 Location in patent:Page/Page column 60