4-(Trifluoromethyl)nicotinonitrile synthesis
- Product Name:4-(Trifluoromethyl)nicotinonitrile
- CAS Number:13600-43-6
- Molecular formula:C7H3F3N2
- Molecular Weight:172.11
13600-42-5
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13600-43-6
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$32.00/1g
Yield: 98.5%
Reaction Conditions:
with pyridine;hydrogen in ethanol at 30; under 760.051 Torr; for 4 h;Green chemistry;Reagent/catalyst;Temperature;Solvent;
Steps:
1-8
Put 25g of 2,6-dichloro-3-cyano-4-trifluoromethylpyridine into a 250 mL four-necked flask, add 100g ethanol, 21g pyridine, and 0.75g homemade Ni-Fe/C bimetallic load in sequence Type catalyst, magnetic stirring, 30 °C normal pressure hydrogenation reaction for 4 hours, after sampling and testing qualified, use Buchner funnel to filter and recover the catalyst, heat to 95-100 to vaporize ethanol and pyridine, extract with toluene, desolvate to obtain 3 -Cyano-4-trifluoromethylpyridine, the content is 98.5%, and the yield is 98.5%.
References:
Shandong Jingbo Biological Technology Co., Ltd.;Zhu Guofu;Li Yanfang;Cheng Daoquan;Wang Lei;Xiang Chuan;Wang Guangjin;Qiu Jinxian;Gao Huan;Yu Lianyou;Wang Hui;Cheng Xiaotong CN112110855, 2020, A Location in patent:Paragraph 0006; 0024-0038
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13600-43-6
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![2-Propenenitrile, 3-[(4,4,4-trifluoro-3-oxo-1-buten-1-yl)amino]-, (2E)-](/CAS/20210305/GIF/533932-96-6.gif)
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13600-43-6
177 suppliers
$32.00/1g
100-54-9
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$5.00/10g
13600-43-6
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$32.00/1g
216431-85-5
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