4-Phenylbutyryl chloride synthesis
- Product Name:4-Phenylbutyryl chloride
- CAS Number:18496-54-3
- Molecular formula:C10H11ClO
- Molecular Weight:182.65
79-37-8
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Yield: 98.1%
Reaction Conditions:
in dichloromethane
Steps:
I.B Synthesis of N-[N-(4-phenyl-1-ketobutane)-(L)-prolyl]-2-(S)-[(5-(3-phenylpropane)-1,2,4-oxadiazolyl)-ketomethane]-pyrrolidine (CQ-0006) STR8 A. N-Benzyloxycarbonyl-2-(S)-(2-acetoxyethanamide oxime)-pyrrolidine hydrochloride.
B. 4-Phenylbutanoyl chloride. To a mixture of 4-phenylbutanoic acid (12.0 g, 0.73 mol) in 60 ml of dichloromethane was added oxalyl chloride (12.8 ml, 0.15 mol). This was then stirred at room temperature until gas evolution ceased (2 hrs.). The reaction mixture was then evaporated to yield a yellow oil (13.1 g, 98.1%) which was used without further purification. IR (neat) 1799.6 cm-1 C=O (acid chloride).
References:
Cortech, Inc. US6159938, 2000, A
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1008-76-0
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18496-54-3
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3360-41-6
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18496-54-3
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