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ChemicalBook CAS DataBase List 4-Nitro-2-(trifluoromethyl)benzoyl chloride
98187-15-6

4-Nitro-2-(trifluoromethyl)benzoyl chloride synthesis

4synthesis methods
4-Nitro-2-(trifluoromethyl)benzoic acid can be obtained by reacting 2-trifluoromethylbenzocyanide and nitrating agent as raw materials.
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sulfuric acid; nitric acid / 20 °C
2.1: methyl iodide; magnesium; iodine / tetrahydrofuran / 3 h / 50 °C / Inert atmosphere
2.2: 2 h / Inert atmosphere
3.1: thionyl chloride / 2 h / Reflux

References:

Shenzhen Daoerdun Electronic Materials Co., Ltd.;Wang Shenglin;Li Houming;Wang Jianxin CN112225676, 2021, A

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